Beamion™ LUNG-3 (1479-0032): A Phase III, randomized, controlled, multi-center trial evaluating zongertinib as an adjuvant monotherapy compared with SOC in patients with early-stage, resectable NSCLC (stage IIIIIB) harboring TKD activating HER2 mutations (NCT07195695)1,2

Beamion™ LUNG-3 (1479-0032)
Beamion™ LUNG-3 (1479-0032)


*Documented TKD activating HER2 mutations; According to country-specific SOC; IO can include pembrolizumab, atezolizumab, durvalumab or nivolumab; Time from randomization until recurrence of tumor or death from any cause, whichever is earlier. 
AE, adverse event; DFS, disease-free survival; ECOG PS, Eastern Cooperative Oncology Group performance status; HER2, human epidermal growth factor receptor 2; IO, immunotherapy; NSCLC, non-small cell lung cancer; OS, overall survival; QD, once daily; SOC, standard of care; TKD, tyrosine kinase domain.

References
  1. ClinicalTrials.gov. NCT07195695. https://clinicaltrials.gov/study/NCT07195695 (Accessed: February 2026).

  2. Boehringer Ingelheim. Data on File.